Endocrine Abstracts

A 37 year old lady presented to her GP with increasing lethergy, bloating and low mood associated with her menstrual periods. Her GP undertook a hormonal screen including androgen profile which revealed elevated 17-Hydroxyprogesterone 25.5 nmol/L (0.1–8.5). The rest of her androgen profile was normal. As a teenager she suffered with acne and hirsutism, for which she had laser therapy, but this had resolved. Periods were regular, every 28 days with 1–2 days menstruati...

Insulinomas, uncommon neuroendocrine tumours, may produce insulin-induced hypoglycemia. It causes neuroglycopenia and autonomic sympathetic dysfunction. Glucose immediately relieves these sensations. Hypoglycemia without plasma sulfonylurea and increased C-peptide is diagnostic. The tumour must be found before surgery.Introduction: Hypoglycemia is caused by insulinomas. Insulinoma, the most frequent functional pancreatic tumour, occurs just four times pe...

Case History: A 19-year-old female presented with painful left shoulder after slipping whilst doing press-ups. Plain x-ray showed a proximal humeral fracture, as well as a large bone cyst raising concerns of a pathological fracture. She had no past medical history and was not taking any regular medications. On further questioning she did complain of a 2 year history of bilateral painful shoulders and left knee pain. Family history was significant for her father suffering prima...

A 37-year-old Nigerian lady was referred to the endocrinology clinic with worsening dyspnoea, weight loss, poor sleep and palpitations over the preceding few months. She had a past history of depression treated with citalopram. She was clinically and biochemically thyrotoxic with a TSH <0.01 μ/l [0.4–5] and free T4 49.3 pmol/l [9–19]. TSH receptor antibodies were positive. She was commenced on carbimazole 40 mg once daily and propranolol 40 mg twi...

A 58-year-old lady presented to hospital with abdominal pain, nausea, and tiredness, and was referred to endocrinology with symptomatic hyponatraemia (serum Na+ 112 mmol/l). Six months previously her serum sodium was normal. She was euvolaemic, and adrenal insufficiency and thyroid dysfunction were excluded. Laboratory investigations were suggestive of syndrome of inappropriate antidiuretic hormone (SIADH) and no causative medications were identified. A CT of her th...

Background: Lifelong surveillance should be offered to people with hereditary phaeochromocytoma and paraganglioma (PPGL), including asymptomatic carriers of pathogenic gene variants. Regular biochemical and radiological surveillance aims to improve disease detection and prognosis. During the COVID-19 pandemic, outpatient appointments were cancelled or postponed. Departments continue to face large backlogs of work. Clinicians in the USA reported 15% PPGL patients missing at lea...